While some people might say that the show isn't the greatest, I have to say that I really love the entire premise behind it. It takes the normal vampire story and throws it on its end by shaking it up a bit.
Firstly, it's set in backwoods Louisiana, not LA, or NY, or some other glamourous, glittery locale. Like the Twilight saga, it uses something other than flash to convey its story. Being set in such a rural place, it makes for some very interesting characters. I like that it depicts small town life accurately (as far as I'm concerned, anyways), with everyone congregating at Merlotte's every night for food and booze. Most of the young men work at the same job (Jason's construction company), and most of the girls work at the bar. I get the impression that Bon Temps is tiny, with only a handful of residents.
Secondly, the world knows about vampires, which is something that hasn't really been explored yet in popular culture. Like any minority, they are being persecuted. There are those who are with them, and those who are against them (i.e. Jesus camp). They don't have to hide in the shadows in True Blood (well, maybe a little). And in addition to the general populace being aware of vampires' existence, they've flipped the coin and made humans crave vampires' blood, because of the stimulant properties 'V' has. So in a society where the killers have been outed, and many are trying to live as peacefully as possible within humanity, you have humans who are hunting them and taking THEIR blood from them. Sometimes, the vampires die. It's a nice reversal on the vampire mythos.
Thirdly, I love that there are other supernatural elements in the series, but they aren't really in your face about it. Sookie is a mind reader.
Sam easily changes shape from man to dog, but it's not a spectacle. In the second season, we see Maryann, who is either a witch, or a God of some sort, who seems to be able to release people's inhibitions and lust... why? I don't know yet.A friend of mine at work compared the show to Twilight, and I had to disagree with her. She said they were very similar. Maybe in the fact that it has the same general formula, 'human girl falls in love with vampire', but this show is SOOOO much more complex than Twilight. The vampires here are responsible for those they turn, they have a law system with each district having its own 'sheriff' (Eric).... Plus, as I said, having the whole dynamic of humankind being aware of their existence on the whole sets it completely apart from much other vampire fiction.
I didn't mean to ramble, I just thought it would be good to add some sort of substance to the thread to get the ball rolling.